signal transduction through il1r
| PAG Title | signal transduction through il1r |
| PAG ID | WAG001462 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Interleukin-1 (IL-1) is a pro-inflammatory cytokine that sigls primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include induction of fever, expression of vascular adhesion molecules, and roles in arthritis and septic shock. The inflammatory activities of IL-1 are partially derived by transcriptiolly inducing expression of cytokines such as TNF-alpha and interferons, as well as inducing the expression of other inflammation-related genes. There are two forms of IL-1 encoded by distinct genes, IL-1 alpha and IL-1 beta. IL-1 beta is produced as a 269 amino acid precursor that is cleaved by IL-1beta converting enzyme (ICE) to the active IL-1 beta form that is secreted. IL-1 sigling is opposed by the turally occurring peptide IL-1 receptor antagonist which is a therapeutic agent for the treatment of arthritis. |
| Species | Homo sapiens |
| nCoCo Score | 4,205 |
| Base PAG ID | WAG001462 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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